Silvestro Giovanni Conticello

This study creates a mouse model with human APOBEC3 genes to study their expression and anti-viral functions, showing human-like regulation and functional responses.

This study demonstrates the ability to detect cell-of-origin and cancer-specific methylation features from cell-free DNA using Oxford Nanopore sequencing.

The paper shows that APOBEC1 dimerisation is critical for its activity and availability, and that dimerisation increases DNA damage.

The paper identifies RNA editing signatures in SARS-CoV-2 transcriptomes, suggesting host deaminases like ADAR and APOBEC contribute to antiviral defense and viral evolution.

This study identifies driver mutations in cancer by analyzing mutational likeliness and entropy, distinguishing them from passenger mutations and differentiating gain and loss of function mutations.