Haydn M. Prosser

Human-like APOBEC3 gene expression and anti-viral responses following replacement of mouse Apobec3 with the 7-gene human APOBEC3 locus

This study creates a mouse model with human APOBEC3 genes to study their expression and anti-viral functions, showing human-like regulation and functional responses.

The imprinted Mir483 is a growth suppressor and metabolic regulator functioning through IGF1

This study identifies Mir483 as a growth suppressor and metabolic regulator that antagonizes its host gene Igf2 through IGF1 signaling, revealing a novel mechanism of growth control.

Hearing impairment due to Mir183/96/182 mutations suggests both loss and gain of function effects

This study investigates the effects of Mir183/96/182 mutations on hearing, finding that loss of these microRNAs causes deafness, while their mutations can lead to both loss and gain of function effects.

Mesenchymal Igf2 is a major paracrine regulator of pancreatic growth and function

This study identifies mesenchymal Igf2 as a critical paracrine regulator of pancreatic growth and function through in vivo and ex vivo experiments.