Verena M. Link

Ketogenic diet synergistic reprogramming of both host and microbiome promotes tissue regeneration

This study shows a ketogenic diet reprograms host and microbiome functions to enhance tissue regeneration through IL-17A activation and microbial riboflavin and sphingomyelinase pathways.

Endogenous retroelements promote tolerance to dietary antigens

This study shows that endogenous retroelements promote tolerance to dietary antigens by regulating regulatory T cell function and dendritic cell activity through innate sensing pathways.

Adaptive immunity to retroelements promotes barrier integrity

The paper shows that mild detergent exposure reactivates retroelements, inducing CD8+ T cells that enhance skin wound repair through IL-17A.

Systematic analysis of transcriptional and epigenetic effects of genetic variation in Kupffer cells enables discrimination of cell intrinsic and environment-dependent mechanisms

The paper analyzes how genetic variation affects gene expression and epigenetics in Kupffer cells, distinguishing between cell intrinsic and environment-dependent mechanisms.

Functional non-coding SNPs in human endothelial cells fine-map vascular trait associations

The paper identifies functional non-coding SNPs in human endothelial cells that influence vascular traits by affecting transcriptional regulation and chromatin states.

Genetic variants drive altered epigenetic regulation of endotoxin tolerance in BTBR macrophages

The paper shows BTBR mouse genetic variants lead to altered chromatin accessibility and hyper-responsive innate immunity in macrophages, linking genetic differences to ASD-related immune abnormalities.

Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells

The paper shows that KDM7A and UTX demethylate repressive histone marks to enable NF-κB-dependent inflammatory gene activation in endothelial cells.

Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages

The paper identifies non-redundant DNA binding activities of AP-1 family members in macrophages using ChIP-sequencing and machine learning, showing motif ensembles drive factor-specific binding.

MARGE: Mutation Analysis for Regulatory Genomic Elements

MARGE identifies collaborative transcription factor pairs by integrating genetic variation with epigenetic data to interpret non-coding genetic variation.