Enhanced yield and subtype identity of hPSC-derived midbrain dopamine neuron by modulation of WNT and FGF18 signaling
Tae Wan Kim, Jinghua Piao, Vittoria Dickinson Bocchi, So Yeon Koo, Se Joon Choi, Fayzan F. Chaudhry, Donghe Yang, Hyunwoo Cho, Emiliano Hergenreder, Lucia Ruiz Perera, Subhashini Joshi, Zaki Abou-Mrad, Nidia Claros, Shkurte Ademi Donohue, Anika K. Frank, , Lorenz Studer
This study improves the yield and subtype identity of hPSC-derived midbrain dopamine neurons through optimized WNT and FGF18 signaling modulation, enhancing their functional and transcriptional similarity to primary neurons.
bioRxiv · Jan 6, 2025 · PreprintCell Biology