Author

Ram Sagar

Johns Hopkins UniversityORCID 0000-0002-4297-2639Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

Vasiliki MahairakiiD· 3 shared Constantine George LyketsosiD· 2 shared Anannya KshirsagariD· 1 shared Annie KathuriaiD· 1 shared Anton B. IliukiD· 1 shared Ariadni XydiaiD· 1 shared Carlos J. Nogueras‐OrtiziD· 1 shared Christian E. BadriD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersNeuroscience

Vasiliki MahairakiORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintApr 29, 2026

Proteomic identification and validation of novel neuronal EV-based markers for Alzheimers disease biomarker discovery

Waqar Ahmed, Carlos J. Nogueras‐Ortiz, Ram Sagar…·Vasiliki Mahairaki

The paper identifies and validates novel neuronal EV surface markers, CNTNAP2 and STX1B, for Alzheimer's disease biomarker discovery through proteomic analysis of EVs from hiPSC-derived neurons and human brain.

DOI 10.64898/2026.04.26.720870

humanproteomics

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BioengineeringbioRxivPreprintJan 20, 2025

Multi-Region Brain Organoid: Fusion Organoid with Cerebral, Endothelial and Mid-Hindbrain Components

Anannya Kshirsagar, Hayk Mnatsakanyan, Sai Kulkarni…·Annie Kathuria

This paper introduces Multi-Region Brain Organoids (MRBOs) that integrate cerebral, mid/hindbrain, and complex endothelial components, revealing new roles for endothelial cells in brain development.

DOI 10.1101/2025.01.20.633788

humanscRNA-seq

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GeneticsCellsPeer-reviewedAug 2, 2023

Excitatory neurons derived from human induced Pluripotent Stem Cells show transcriptomic differences in Alzheimers patients from controls

Ram Sagar, Ioannis Azoidis, Cristina Zivko…·Dimitrios Avramopoulos

The paper compares transcriptomes of excitatory neurons from Alzheimer's patients and controls, identifying 621 differentially expressed genes and linking them to known Alzheimer's genes and functional networks.

9 citations

humanbulk RNA-seq

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