Luca Ravotto

PURELIGHT improves photon efficiency and accuracy in fluorescence microscopy by recovering undistorted intensity and lifetime measurements at high count rates across multiple detector technologies.

This study shows neurons switch fuel sources from glucose to lactate when extracellular lactate increases, regardless of activity, revealing lactate availability as the key factor.

The paper introduces ECgo, an optical method to induce single endothelial cell injury and capillary occlusion in the mouse brain with high spatial precision, enabling studies of capillary repair and dysfunction.

This study shows that abnormal astrocyte activity during adolescent prefrontal cortex development leads to synaptic loss, interneuron dysfunction, and cognitive deficits.

The paper examines energy metabolism in retinal neurons, showing photoreceptors use both aerobic glycolysis and OXPHOS while inner retinal neurons rely on OXPHOS, and identifies metabolic changes in a retinitis pigmentosa mutation.

This study investigates how different APOE genotypes affect human astrocytic energy metabolism, finding reduced ATP production in APOE4 astrocytes but increased mitochondrial respiration and glycolytic capacity.

The paper investigates how dopamine transmission and mating drive change over days in male mice, finding two mechanisms that regulate these slow-timescale dynamics.

This paper introduces a low-cost FPGA-based method to correct pile-up distortions in TCSPC-FLIM, enabling high-speed, accurate in vivo imaging with subcellular resolution.

This paper develops a genetically encoded biosensor for dynamically monitoring PTEN activity in living cells and tissues with high spatial and temporal resolution.

This paper develops a genetically encoded sensor, NOPLight, to detect endogenous N/OFQ release with high spatial and temporal resolution in vitro and in vivo.

The paper shows that mature astrocytes can transform into progenitor-like cells to regenerate astrocytic networks after injury in mice.

This study shows that oligodendrocytes use potassium signaling to regulate axonal metabolism and maintain axonal health through metabolic coupling.