Author

Shruti V. Iyer

Cold Spring Harbor LaboratoryORCID 0000-0002-4351-9975Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:long-read sequencing· 1 Assay:organoid / primary culture· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Melissa KrameriD· 2 shared William Richard McCombieiD· 2 shared Alexey S. RevenkoiD· 1 shared David L. SpectoriD· 1 shared Disha AggarwaliD· 1 shared Gayatri AruniD· 1 shared James A. RouseiD· 1 shared John Erby WilkinsoniD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

Melissa KramerORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Patient-derived organoid xenografts reveal the multifaceted role of the lncRNA MALAT1 in breast cancer progression

Disha Aggarwal, Suzanne Russo, Kendall L. Anderson, Taylor Floyd, Raditya Utama, James A. Rouse, Payal K. Naik, Sara A Pawlak, Shruti V. Iyer, Melissa Kramer, Shuchismita R. Satpathy, John Erby Wilkinson, Qing Gao, Sonam Bhatia, Gayatri Arun, , David L. Spector

This study evaluates MALAT1-targeting ASOs in breast cancer using patient-derived organoid models, showing MALAT1's role in alternative splicing, metastasis, and tumor-stroma interactions.

bioRxiv · Jun 27, 2026 · PreprintCancer Biology

ACME: an Affinity-based Cas9 Mediated Enrichment method for targeted nanopore sequencing

Shruti V. Iyer, Melissa Kramer, Sara Goodwin, William Richard McCombie

ACME improves targeted nanopore sequencing by increasing enrichment, depth, and read coverage for specific genomic regions.

bioRxiv · Feb 3, 2022 · PreprintGenomics