Patient-derived organoid xenografts reveal the multifaceted role of the lncRNA MALAT1 in breast cancer progression
Disha Aggarwal, Suzanne Russo, Kendall L. Anderson, Taylor Floyd, Raditya Utama, James A. Rouse, Payal K. Naik, Sara A Pawlak, Shruti V. Iyer, Melissa Kramer, Shuchismita R. Satpathy, John Erby Wilkinson, Qing Gao, Sonam Bhatia, Gayatri Arun, , David L. Spector
This study evaluates MALAT1-targeting ASOs in breast cancer using patient-derived organoid models, showing MALAT1's role in alternative splicing, metastasis, and tumor-stroma interactions.
bioRxiv · Jun 27, 2026 · PreprintCancer Biology