PTP1B supports survival and regulates CFL1 and HSP90a abundance in trastuzumab-resistant HER2-positive breast cancer.
Vinay Mandati, Maria C. Panepinto, Christy Felice, Sean Krivitsky, Suzanne Russo, Payal K. Naik, Raditya Utama, David L. Spector, Paolo Cifani, Nicholas K. Tonks
This study identifies PTP1B as a survival dependency in trastuzumab-resistant HER2-positive breast cancer, showing it regulates CFL1 and HSP90a abundance through dephosphorylation.
bioRxiv · Oct 28, 2026 · PreprintCancer Biology