Yichun Wang

Nanochiral graphene quantum dots preferentially target virus-organized membrane states for host-sparing antiviral activity

This paper shows that D-His-GQDs selectively target virus-organized membrane domains, disrupting viral envelopes while sparing host cells, with antiviral activity against multiple enveloped viruses.

Music-Inspired Acoustic-Piezoelectric Stimulation Accelerates Extracellular Vesicle Production and Programs Therapeutic Function

This study uses music-inspired acoustic-piezoelectric stimulation to enhance macrophage extracellular vesicle production and control their therapeutic function by tuning polarization states.

Dual-Engineered Dendritic Cell Derived Small Extracellular Vesicles Couple T Cell Priming with Checkpoint Reprogramming for Synergistic Immunotherapy

This paper develops engineered dendritic cell-derived small extracellular vesicles that combine T-cell priming with checkpoint reprogramming to enhance antitumor immunity.

Distinct Chiral Nanostructures of Graphene Quantum Dots Govern Divergent Passive and Active Enantioselective Transport across Biological Membranes

This study investigates how chiral ligand modulated graphene quantum dots (GQDs) form distinct nanostructures that influence passive and active enantioselective transport across biological membranes.

M1 Macrophage-Derived Small Extracellular Vesicles as Synergistic Nanotherapeutics: Harnessing Intrinsic Anticancer Activity and Drug Delivery Capacity

This study demonstrates that M1 macrophage-derived small extracellular vesicles (sEVs) act as dual-action nanotherapeutics by combining innate immune-regulatory functions with drug delivery, achieving synergistic anticancer effects.

Nanochirality-programmed Type-I photosensitizer enables deep-tumor photodynamic therapy by reducing extracellular-matrix adhesion

This paper develops a nanochirality-programmed photosensitizer for deep-tumor PDT by enhancing ROS production and reducing matrix adhesion.

Automated High-Content, High-Throughput Spatial Analysis Pipeline for Drug Screening in 3D Tumor Spheroid Inverted Colloidal Crystal Arrays

This paper introduces a 3D high-content, high-throughput platform for drug screening in tumor spheroids, showing faster and more spatially informative analysis than conventional methods.

N-Amino Peptide-Graphene Quantum Dot Loaded Small Extracellular Vesicles for Targeted Therapy of Tauopathies

This study develops N-Amino Peptide-Graphene Quantum Dot loaded small extracellular vesicles to target tauopathies, showing improved specificity and efficacy in inhibiting tau aggregation and transmission.

A Bioinert Hydrogel Framework for Precision 3D Cell Cultures: Advancing Automated High-Content and High-Throughput Drug Screening

This paper introduces a bioinert hydrogel framework for creating uniform 3D cell cultures to enable high-content and high-throughput drug screening.

Stimulative piezoelectric nanofibrous scaffolds for enhanced small extracellular vesicle production in 3D cultures

This paper develops a 3D culture platform using piezoelectric nanofibrous scaffolds with acoustic stimulation to significantly enhance small extracellular vesicle production.