Xin Lü

Establishment and characterization of LNCaP-TR-BoM, a bone metastasis-derived prostate cancer cell line with an intermediate AR-attenuated phenotype

This paper establishes and characterizes LNCaP-TR-BoM, a bone metastasis-derived prostate cancer cell line with an intermediate AR-attenuated phenotype, showing transcriptomic and functional similarities to metastatic castration-resistant prostate cancer.

Synthetic essentiality of TRAIL/TNFSF10 in VHL-deficient renal cell carcinoma

This study identifies TRAIL as a synthetic essentiality in VHL-deficient ccRCC, showing its regulation by HIF2 and its role in cell proliferation through the p38 MAPK pathway, suggesting a combination therapy strategy.

Dual-Engineered Dendritic Cell Derived Small Extracellular Vesicles Couple T Cell Priming with Checkpoint Reprogramming for Synergistic Immunotherapy

This paper develops engineered dendritic cell-derived small extracellular vesicles that combine T-cell priming with checkpoint reprogramming to enhance antitumor immunity.

M1 Macrophage-Derived Small Extracellular Vesicles as Synergistic Nanotherapeutics: Harnessing Intrinsic Anticancer Activity and Drug Delivery Capacity

This study demonstrates that M1 macrophage-derived small extracellular vesicles (sEVs) act as dual-action nanotherapeutics by combining innate immune-regulatory functions with drug delivery, achieving synergistic anticancer effects.

CDH3 as a Novel Therapeutic Target in Basal-like Double-Negative Prostate Cancer

This study identifies CDH3 as a key driver of basal-like prostate cancer and shows that CDH3-targeted therapies like ADCs and CAR T cells are effective in preclinical models.

An oncogenotype-immunophenotype paradigm governing the myeloid landscape in genetically engineered mouse models of prostate cancer

The paper identifies a Smad4-loss-driven neutrophil-enriched subtype in prostate cancer models and shows that targeting epigenetic enzymes can suppress tumor growth.

Comparative Analysis of 3D Culture Methodologies in Prostate Cancer Cells

This study compares 3D culture scaffolds for prostate cancer cells, finding scaffold-dependent differences in spheroid formation and gene expression, particularly in neuroendocrine markers.

DiCE: Differential Centrality-Ensemble Analysis Based on Gene Expression Profiles and Protein-Protein Interaction Network

DiCE identifies disease-associated genes by combining differential expression with network centrality analysis, validated on prostate cancer datasets to find genes correlated with disease-free survival.

Novel 3-D macrophage spheroid model reveals reciprocal regulation of immunomechanical stress and mechano-immunological response

This study shows macrophages generate mechanical stress in agarose gels and respond to environmental stiffness and cytokine signals.

CDHu40: a novel marker gene set of neuroendocrine prostate cancer (NEPC)

The paper identifies a novel marker gene set, CDHu40, for neuroendocrine prostate cancer (NEPC) using gene expression and PPI network analysis, showing strong prognostic significance.

HSF1 excludes CD8+ T cells from breast tumors via suppression of CCL5

This study shows HSF1 suppresses CD8+ T cell infiltration in breast tumors by reducing CCL5 expression, thereby preventing immune-mediated tumor destruction.