Lieve Moons

The paper identifies an interferon-responsive oligodendroglial state in aging white matter using killifish models, linking it to potential neurodegenerative disease mechanisms.

The paper shows that dendritic pruning, linked to suppressed mTORC1 signaling, supports axonal regeneration in zebrafish, revealing a trade-off between dendritic preservation and axonal growth.

This paper introduces human myelin spheres (MyS) as a model for studying myelination and demyelination, showing their ability to form myelinated neurons and mimic in vivo oligodendrocyte development.

MyeliMAP models human CNS myelination using hPSC-derived neurons and oligodendrocytes in a microfluidic platform, showing enhanced action potential conduction and stabilized network activity.

The paper compares retinal ganglion cell resilience to optic nerve injury across mice, zebrafish, and killifish, revealing species-specific differences in RGC density and injury response.

This study shows that retinal ganglion cell regenerative potential is linked to their developmental maturation timeline, with sON cells showing greater injury-induced regression than tON cells.

The paper identifies metabolic reprogramming in zebrafish axonal regeneration and shows its conservation in mammals, suggesting therapeutic potential for CNS regeneration.

The paper shows that local glycolysis supports axonal regeneration after injury by providing ATP, complementing mitochondrial metabolism.

This study investigates the role of oligodendroglia in Wolfram syndrome using mouse models and iPSC-derived cells, finding preserved oligodendroglia function and suggesting alternative targets for treatment.

This study uses bulk and single-cell RNA-seq to analyze age-related transcriptome changes in the African turquoise killifish retina, identifying oxidative stress, gliosis, and inflammageing, and highlighting dysregulation of retinal disease genes.

The paper optimizes a whole-mount multiplexed RNA in situ hybridization chain reaction (HCR v3.0) protocol combined with immunohistochemistry and imaging to visualize neurogenesis in octopus embryos.

This study shows that aging impairs neurorepair in killifish by reducing non-glial progenitor activity and increasing inflammation and glial scarring.

This study shows CRF rapidly alters synaptic function and structure in hippocampal CA1 neurons during acute stress, enhancing synaptic communication and memory consolidation.

This study shows that the AppNL-G-F mouse retina accumulates Aβ early and exhibits AD-like features, suggesting it as a model for preclinical AD research and diagnosis.