This study shows Dock8 regulates mechanosensitive actin redistribution in immune cells, maintaining cohesion and protecting the nucleus during migration through confined environments.

Science Immunology · Jun 26, 2025Peer-reviewedImmunology

C1orf112 is a novel regulator of interstrand crosslink that decreases FIGNL1-RAD51 interaction

Edgar Pinedo Carpio, Julien Dessapt, Romain Villot, Lauralicia Sacre, Abba Malina, Jonathan Boulais, Élise G. Lavoie, Vincent Mingyi Luo, Anna-Maria Lazaratos, Jean‐François Côté, Frédérick A. Mallette, Alba Guarné, Amélie Fradet‐Turcotte, Alexandre Orthwein

The paper identifies C1orf112 as a novel regulator of interstrand crosslinks that decreases FIGNL1-RAD51 interaction, impairing homology-directed repair.

bioRxiv · Oct 6, 2022 · PreprintMolecular Biology

POGZ modulates the DNA damage response in a HP1-dependent manner

John Heath, Estelle R. Simo‐Cheyou, Steven Findlay, Vincent Mingyi Luo, Edgar Pinedo Carpio, Jeesan Lee, Billel Djerir, Xiaoru Chen, Théo Morin, Benjamin Lebeau, Martin Karam, Halil Bagci, Damien Grapton, Josie Ursini‐Siegel, Jean‐François Côté, , Alexandre Orthwein

This study identifies POGZ as a regulator of HP1-dependent DNA repair, showing its role in homology-directed repair and its clinical relevance to White Sutton syndrome.

bioRxiv · Jun 28, 2021 · PreprintMolecular Biology

The impact of endogenous retroviruses on nuclear organization and gene expression

Ramya Raviram, Pedro P. Rocha, Vincent Mingyi Luo, Emily Swanzey, Emily R. Miraldi, Edward B. Chuong, Cédric Feschotte, Richard Bonneau, Jane A. Skok

The paper introduces 4Tran, a method to study transposon interactions in the genome, revealing their role in chromatin organization and gene regulation.

bioRxiv · Apr 6, 2018 · PreprintGenomics