Andrea Kranz

This study shows MLL2 stabilizes 3D chromatin loops during pluripotent cell differentiation without requiring its enzymatic activity.

This study shows that loss of SETD1B in oocytes causes redistribution of H3K4me3, with loss at active promoters and gain at CpG-rich regions, revealing distinct roles for SETD1B and MLL2 in epigenetic regulation.

This study shows that SETD1B is crucial for learning and regulates neuronal plasticity genes in the postnatal brain through H3K4me3 modification.

This study shows that MLL1 is essential for intestinal stem cell maintenance and regulates the expression of JAML, a cell adhesion molecule critical for stem cell niche interactions.

The paper shows that Setd1b regulates neuronal identity genes in the adult brain, affecting cognitive function and memory, with other KMTs compensating for its absence.

The paper investigates the distinct developmental roles of MLL3 and MLL4 in mice, finding MLL4 is critical for early embryonic migration while MLL3 is needed for lung maturation.