Author

Courtney W. Hanna

Babraham InstituteORCID 0000-0002-4063-5575Unclaimed ORCID profile · follow to get notified of new preprints

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Research Focus:differential expression· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Assay:DNA methylation· 3 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

Gavin KelseyiD· 3 shared Simon AndrewsiD· 2 shared A Francis Stewart· 1 shared Afshan McCarthyiD· 1 shared Alex Faulkner· 1 shared Andrea KranziD· 1 shared Andreas DahliD· 1 shared Anne Segonds-PichoniD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersDevelopmental Biology

Gavin KelseyORCID

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4 papers

Recent·Most cited

Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst

Claire S. Simon, Afshan McCarthy, Laura M. Woods, Desislava P. Staneva, Martin Proks, Nazmus Salehin, Georgia Lea, Qiulin Huang, Madeleine Linneberg-Agerholm, Alex Faulkner, Athanasios Papathanasiou, Kay T. Elder, Phil Snell, Leila Christie, Patricia Garcia, , Kathy K. Niakan

The paper shows that inhibiting ERK signaling expands epiblast cells capable of becoming naive pluripotent stem cells in humans, while FGF stimulation expands hypoblast markers.

Nature Communications · Jul 28, 2025Peer-reviewedDevelopmental Biology

Multi-omics analysis demonstrates a critical role for GLP methyltransferase in transcriptional repression during oogenesis

Hannah Demond, Courtney W. Hanna, Juan Castillo Fernandez, Fátima Santos, Evangelia K. Papachristou, Anne Segonds-Pichon, Kamal Kishore, Simon Andrews, Clive S. D’Santos, Gavin Kelsey

The paper investigates the role of GLP methyltransferase in oocyte development using multi-omics analysis and mouse models, finding that GLP contributes to transcriptional repression and is critical for oogenesis.

Genome Research · Jan 1, 2023Peer-reviewedDevelopmental Biology

Loss of histone methyltransferase SETD1B in oogenesis results in the redistribution of genomic histone 3 lysine 4 trimethylation

Courtney W. Hanna, Jiahao Huang, Christian Belton, Susanne Reinhardt, Andreas Dahl, Simon Andrews, A Francis Stewart, Andrea Kranz, Gavin Kelsey

This study shows that loss of SETD1B in oocytes causes redistribution of H3K4me3, with loss at active promoters and gain at CpG-rich regions, revealing distinct roles for SETD1B and MLL2 in epigenetic regulation.

Nucleic Acids Research · Jan 25, 2022Peer-reviewedDevelopmental Biology

Single cell multi-omics profiling reveals a hierarchical epigenetic landscape during mammalian germ layer specification

Ricard Argelaguet, Hisham Mohammed, Stephen J. Clark, L. Carine Stapel, Christel Krueger, Chantriolnt-Andreas Kapourani, Yunlong Xiang, Courtney W. Hanna, Sébastien A. Smallwood, Ximena Ibarra-Soria, Florian Buettner, Guido Sanguinetti, Felix Krueger, Wei Xie, Peter J. Rugg‐Gunn, , Wolf Reik

The paper uses single cell triple-omics analysis to reveal how epigenetic changes drive germ layer specification in mouse embryos, showing distinct epigenetic priming and remodeling in different lineages.

bioRxiv · Jan 13, 2019 · PreprintDevelopmental Biology