Vincent Vanoosthuyse

The paper develops iCoRD to rapidly deliver RNase H1 in live cells and shows it affects specific RNA:DNA hybrids and replication fork stability.

This study shows that rapid delivery of RNase H1 rescues replication fork progression under stress without affecting R-loops.

This study shows that SenataxinSen1 promotes RNA Polymerase III transcription termination in fission yeast independently of R-loops.

This study shows that the sequence of the non-template strand determines the three-dimensional architecture of R-loops, which influences their impact on genome stability.

This study shows that dsRNAs interfere with R-loop detection using S9.6 antibody-based DRIPc-seq in fission yeast, revealing genuine R-loops and their transcriptomic impact.