The rapid delivery of RNase H variants reveals distinct classes of RNA:DNA hybrids
Yara Bawadi, Amandine Basille, Yi‐Ching Lin, Connor Kirke, Clara Bourgeay, David Cluet, Laetitia Vachez, Virgile Dervieux, Laura Guiguettaz, Pascal Bernard, Stephan Hamperl, Philippe Pasero, Emiliano P. Ricci, Vincent Vanoosthuyse
The paper develops iCoRD to rapidly deliver RNase H1 in live cells and shows it affects specific RNA:DNA hybrids and replication fork stability.
bioRxiv · Sep 24, 2026 · PreprintMolecular Biology