Falak Sher

The paper uses CRISPR mapping to identify pharmacological targets for modulating microglial migration linked to Alzheimer's disease.

CRISPRtile is a cloud-based platform that uses AI to improve drug design by predicting functional modulators with reduced error and computational cost.

The paper introduces a proteomic tool to identify protein markers for human microglial states and validates their utility in purification and differentiation.

CRISPR-SURF deconvolves CRISPR tiling screen data to identify functional regulatory elements across CRISPR-Cas, CRISPRi, and CRISPRa experiments.

CRISPRO maps guide RNA functional scores to genomic and structural coordinates, enabling structure-function relationship analysis and improved guide RNA efficacy prediction.