Julie A. Siegenthaler

This study identifies perivascular fibroblasts as regulators of cerebral vasomotion and cerebrospinal fluid movement through calcium dynamics and Gq signaling.

This study identifies GPR182 as a lipoprotein receptor that mediates dietary fat absorption and shows its role in obesity resistance.

This study shows that GBS infection increases arachnoid barrier permeability in neonatal mice, driven by cytokine production from fibroblasts and macrophages.

This study shows that PDGFR signaling is essential for postnatal development of perivascular fibroblasts in the brain.

This study identifies two progenitor sources for kidney lymphatics in mice: Tie2 endothelial lineage and Osr1 intermediate mesoderm, showing a dual origin for kidney lymphatic formation.

This study identifies meningeal-derived retinoic acid's role in suppressing Notch and Sox2 to regulate neurogenesis in neocortical progenitors.

The paper identifies a novel fibroblast subtype in the choroid plexus that forms a barrier between the choroid plexus stroma, brain, and cerebrospinal fluid.

This study tracks the origin and development of perivascular fibroblasts in postnatal mice, showing they originate from the meninges and expand via proliferation and migration to cover cerebral vasculature by P14.

This study shows that retinoic acid signaling in endothelial cells is critical for early retinal angiogenesis, but the vasculature can recover by P15.

The paper identifies Wnt-β-catenin signaling repression as key to arachnoid barrier cell specification in mouse meninges and shows its role in preventing pathogen entry during development.

The paper develops techniques to visualize fibroblast-vessel interactions in the CNS, improving upon traditional methods through whole mount and clearing approaches combined with immunohistochemistry.

VINE-seq yields 143,793 single-nucleus transcriptomes of human brain vascular and perivascular cells; 30 of the top 45 Alzheimer's GWAS genes are expressed there, many microglial in mice.

This study creates a cellular atlas of developing meningeal fibroblasts in mice and humans, revealing distinct subtypes and their functional roles in CNS development.