Convergent evolution on RBA1 regulates Candidozyma auris host adaptation
Laura A. Doorley, Alyssa Ann La Bella, Sarah J. Jones, Guolei Zhao, Mohammad Asadzadeh, Quanita J. Choudhury, Suhail Ahmad, Eiman M. Mokaddas, Inaam Al‐Obaid, Wadha Ahmed Alfouzan, Khalifa Al-Banwan, Teresa R. O’Meara, Felipe Hiram Santiago-Tirado, Ana Lidia Flores‐Mireles, Jeffrey M. Rybak
This study identifies loss-of-function mutations in RBA1 as a convergent adaptation in C. auris that enhances its ability to adhere, form biofilms, and cause infections.
bioRxiv · Dec 23, 2025 · PreprintMicrobiology