An acyclic nucleoside phosphonate effectively blocks the egress of the malaria parasite by inhibiting the synthesis of cyclic GMP.
Mansour Jadaan Ali, Rea Dura, Marc-Antoine Guery, Emma Colard-Itté, Thomas Cheviet, Léa Robresco, Laurence Berry, Corinne Lionne, Catherine Lavazec, Antoine Claessens, Suzanne Peyrottes, Kai Wengelnik, Sharon Wein, Rachel Cerdan
This study identifies UA2239, an acyclic nucleoside phosphonate, as a first-in-class antimalarial that inhibits parasite egress by targeting guanylate cyclase, with dual anti-growth and anti-transmission effects.
Science Advances · Nov 21, 2025Peer-reviewedMicrobiology