MicrobiologyScience AdvancesPeer-reviewed
An acyclic nucleoside phosphonate effectively blocks the egress of the malaria parasite by inhibiting the synthesis of cyclic GMP.
Mansour Jadaan Ali, Rea Dura, Marc-Antoine Guery…·Rachel Cerdan
This study identifies UA2239, an acyclic nucleoside phosphonate, as a first-in-class antimalarial that inhibits parasite egress by targeting guanylate cyclase, with dual anti-growth and anti-transmission effects.
DOI 10.1126/sciadv.ady2859