Catherine Lavazec

This study identifies UA2239, an acyclic nucleoside phosphonate, as a first-in-class antimalarial that inhibits parasite egress by targeting guanylate cyclase, with dual anti-growth and anti-transmission effects.

This study identifies PfPP1 as a critical regulator of Plasmodium falciparum gametocyte persistence and activation, essential for malaria transmission to mosquitoes.

This study identifies PP1 phosphatase as a dual regulator of the malaria parasite's egress pathway, controlling cGMP homeostasis and vacuole rounding-up.