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Author

María José Lafuente-Monasterio

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GlaxoSmithKline (Spain)ORCID 0000-0002-4583-9649Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2Approach:experimental assay· 2Organism:mouse· 2Organism:human· 1Assay:proteomics· 1

Frequent Co-Authors

Alison RothiD· 1 sharedArne AlderiD· 1 sharedCharisse Flerida A. PasajeiD· 1 sharedChristian ScheureriD· 1 sharedConner L. JacksoniD· 1 sharedDale TayloriD· 1 sharedDavid A. FidockiD· 1 sharedDavid CalvoiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr
012022: 1 paper (click to filter)120222023: 0 papers20232024: 0 papers20242025: 0 papers20252026: 1 paper (click to filter)12026

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links
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Lafuente-Mon…Alison Roth · 1 shared paperRoth · 1Conner L. Jackson · 1 shared paperJackson · 1David Calvo · 1 shared paperCalvo · 1Arne Alder · 1 shared paperAlder · 1Charisse Flerida A. Pasaje · 1 shared paperPasaje · 1Christian Scheurer · 1 shared paperScheurer · 1Dale Taylor · 1 shared paperTaylor · 1David A. Fidock · 1 shared paperFidock · 1Dina Coertzen · 1 shared paperCoertzen · 1Elizabeth A. Winzeler · 1 shared paperWinzeler · 1
Focal author (center)Selected co-authorORCID co-authorUnlinked name
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1 shared paperMolecular Biology
Alison RothORCID

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2 papers

Recent·Most cited

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against the Human Malaria Parasite Plasmodium falciparum via Polypharmacological Inhibition of PfArk1 and Hemozoin Formation

Kathryn J. Wicht, John G. Woodland, Larnelle F. Garnie, Henrico Langeveld, Dale Taylor, Luiz Claudio Godoy, Charisse Flerida A. Pasaje, Mariana Laureano de Souza, Jair L. Siqueira-Neto, Sonja Ghidelli, María José Lafuente-Monasterio, Francisco‐Javier Gamo, Dina Coertzen, Janette Reader, Mariëtte van der Watt, , Kelly Chibale

This study shows that CHIR-124, a human Chk1 inhibitor, is active against Plasmodium falciparum through dual inhibition of PfArk1 and hemozoin formation, suggesting polypharmacology as a strategy for antimalarial drugs.

ACS Chemical Biology · Jun 13, 2026Peer-reviewedMicrobiology