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Author

Mariëtte van der Watt

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University of PretoriaORCID 0000-0002-9933-8647Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2Approach:experimental assay· 2Organism:human· 1Organism:mouse· 1Assay:proteomics· 1

Frequent Co-Authors

Charisse Flerida A. PasajeiD· 2 sharedElizabeth A. WinzeleriD· 2 sharedHenrico LangeveldiD· 2 sharedJacquin C. NilesiD· 2 sharedKathryn J. WichtiD· 2 sharedKelly ChibaleiD· 2 sharedLauren B. CoulsoniD· 2 sharedLuiz Claudio GodoyiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr
012025: 1 paper (click to filter)120252026: 1 paper (click to filter)12026

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links
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WattCharisse Flerida A. Pasaje · 2 shared papersPasaje · 2Elizabeth A. Winzeler · 2 shared papersWinzeler · 2Henrico Langeveld · 2 shared papersLangeveld · 2Jacquin C. Niles · 2 shared papersNiles · 2Kathryn J. Wicht · 2 shared papersWicht · 2Kelly Chibale · 2 shared papersChibale · 2Lauren B. Coulson · 2 shared papersCoulson · 2Luiz Claudio Godoy · 2 shared papersGodoy · 2Lyn‐Marié Birkholtz · 2 shared papersBirkholtz · 2Mariana Laureano de Souza · 2 shared papersSouza · 2
Focal author (center)Selected co-authorORCID co-authorUnlinked name
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2 shared papersMicrobiology
Charisse Flerida A. PasajeORCID

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2 papers

Recent·Most cited

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against the Human Malaria Parasite Plasmodium falciparum via Polypharmacological Inhibition of PfArk1 and Hemozoin Formation

Kathryn J. Wicht, John G. Woodland, Larnelle F. Garnie, Henrico Langeveld, Dale Taylor, Luiz Claudio Godoy, Charisse Flerida A. Pasaje, Mariana Laureano de Souza, Jair L. Siqueira-Neto, Sonja Ghidelli, María José Lafuente-Monasterio, Francisco‐Javier Gamo, Dina Coertzen, Janette Reader, Mariëtte van der Watt, , Kelly Chibale

This study shows that CHIR-124, a human Chk1 inhibitor, is active against Plasmodium falciparum through dual inhibition of PfArk1 and hemozoin formation, suggesting polypharmacology as a strategy for antimalarial drugs.

ACS Chemical Biology · Jun 13, 2026Peer-reviewedMicrobiology