Miguel Constância

Rewiring of chromatin loops in adipogenesis reveals targets for obesity and diabetes intervention

The paper identifies chromatin loop rewiring in adipogenesis and discovers novel regulators and gene-trait associations relevant to obesity and diabetes.

Fetal manipulation of maternal metabolism is a critical function of Igf2 imprinting

This study shows that Igf2 imprinting in mouse placental endocrine cells is critical for fetal manipulation of maternal metabolism, leading to nutrient allocation and offspring metabolic health outcomes.

The imprinted Mir483 is a growth suppressor and metabolic regulator functioning through IGF1

This study identifies Mir483 as a growth suppressor and metabolic regulator that antagonizes its host gene Igf2 through IGF1 signaling, revealing a novel mechanism of growth control.

The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth

This study shows that the imprinted Igf2-Igf2r axis is essential for coordinating placental microvasculature expansion with fetal growth in mice.

Mesenchymal Igf2 is a major paracrine regulator of pancreatic growth and function

This study identifies mesenchymal Igf2 as a critical paracrine regulator of pancreatic growth and function through in vivo and ex vivo experiments.

Fetal and trophoblast PI3Kp110α have distinct roles in regulating resource supply to the growing fetus

This study investigates the distinct roles of fetal and trophoblast PI3Kp110α in regulating nutrient supply to the fetus, showing differential effects on placental function and fetal growth.