Author

Cristian Rocha‐Roa

University of FribourgORCID 0000-0002-4602-6121Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Organism:plant (other)· 1

Frequent Co-Authors

Stefano VanniiD· 4 shared Daniel ÁlvareziD· 3 shared Elizabeth ConibeariD· 2 shared Michael DaveyiD· 2 shared Paige Chandran BlairiD· 2 shared Ana Ribeiro-Holbein· 1 shared Andrés Guillén-SamanderiD· 1 shared Bodan HuiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersCell Biology

Stefano VanniORCID

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4 papers

Recent·Most cited

A new class of lipid transfer proteins is required for the recycling of lipids from the P. falciparum digestive vacuole

Andrés Guillén-Samander, Yara Ahmed, Ana Ribeiro-Holbein, José Cubillán-Marín, Katharina Höhn, Cristian Rocha‐Roa, Jana Dröge, Lea S. Panitzsch, Paul‐Christian Burda, Tim‐Wolf Gilberger, Stefano Vanni, Tobias Spielmann

The paper identifies PfTUPA, a novel lipid transfer protein in Plasmodium falciparum essential for lipid recycling from the digestive vacuole.

bioRxiv · Sep 12, 2026 · PreprintMicrobiology

The molecular mechanism of lipid uptake by membrane-anchored bridge-like lipid transfer proteins.

Daniel Álvarez, Paige Chandran Blair, Cristian Rocha‐Roa, Michael Davey, Elizabeth Conibear, Stefano Vanni

This study uses molecular dynamics simulations to reveal the mechanism of lipid transport by BLTPs, showing membrane destabilization is critical for lipid desorption.

Proceedings of the National Academy of Sciences · Jan 21, 2026Peer-reviewedBiophysics

Molecular insights into bulk lipid transport from structural studies of the bridge-like protein VPS13A complexed with the scramblase XKR1

Bodan Hu, Daniel Álvarez, Cristian Rocha‐Roa, Valentin Guyard, Dazhi Li, Xinbo Wang, Pietro V. De Camilli, Stefano Vanni, Karin M. Reinisch

The paper uses cryo-EM to study the VPS13A-XKR1 complex, revealing how it facilitates lipid transfer between membranes and how this process is enhanced by membrane properties.

bioRxiv · Jan 8, 2026 · PreprintCell Biology

TMEM170 family proteins are lipid scramblases that physically associate with bridge lipid transporters BLTP1/Csf1

Cristian Rocha‐Roa, Gurpreet Sidhu, Paige Chandran Blair, Daniel Álvarez, Michael Davey, Elizabeth Conibear, Stefano Vanni

The paper identifies TMEM170 family proteins as lipid scramblases that physically interact with BLTP1/Csf1, revealing a new mechanism for lipid transport between organelles.

bioRxiv · Apr 30, 2025 · PreprintCell Biology