Tim‐Wolf Gilberger

A new class of lipid transfer proteins is required for the recycling of lipids from the P. falciparum digestive vacuole

The paper identifies PfTUPA, a novel lipid transfer protein in Plasmodium falciparum essential for lipid recycling from the digestive vacuole.

Characterization of Host Cell Cytosol-filled Vesicles in the Human Malaria Parasite Plasmodium falciparum

This study characterizes Hb-filled vesicles (HbVs) in Plasmodium falciparum, identifying their morphology, molecular composition, and a Rab-regulatory component involved in endosomal transport.

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against the Human Malaria Parasite Plasmodium falciparum via Polypharmacological Inhibition of PfArk1 and Hemozoin Formation

This study shows that CHIR-124, a human Chk1 inhibitor, is active against Plasmodium falciparum through dual inhibition of PfArk1 and hemozoin formation, suggesting polypharmacology as a strategy for antimalarial drugs.

Malaria parasite HOPS/CORVET complexes are critical for endocytosis and invasion organelles function

This study shows that HOPS/CORVET complexes are essential for malaria parasite endocytosis and invasion organelle function, with distinct roles in different developmental stages.

Comparative proteomics of vesicles essential for the egress of Plasmodium falciparum gametocytes from red blood cells

The paper identifies novel proteins in Plasmodium falciparum gametocyte egress vesicles using imaging and BioID, revealing distinct proteomes for osmiophilic bodies and g-exonemes.

A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture

The paper introduces a new computational pipeline for var gene expression analysis, showing changes in var gene expression and core transcriptome during in vitro culture of Plasmodium falciparum.

A microtubule associated protein is essential for malaria parasite transmission

This paper identifies a novel microtubule-associated protein, SPM3, essential for malaria parasite transmission by affecting gametocyte morphology and sporozoite motility.

PMRT1, a Plasmodium specific parasite plasma membrane transporter is essential for asexual and sexual blood stage development

The paper investigates six membrane transporters in Plasmodium falciparum, finding four essential for asexual development and one essential for gametocytogenesis.

Characterization of apicomplexan amino acid transporters (ApiATs) in the malaria parasite Plasmodium falciparum

This study characterizes ApiATs in Plasmodium falciparum, showing their localization to the parasite plasma membrane and partial redundancy in asexual proliferation but not gametocytogenesis.

Gene expression profiling of malaria parasites reveals common virulence gene expression in adult first-time infected patients and severecases

The paper identifies PfEMP1 variants associated with severe malaria in first-time infected adults and non-severe cases using RNA-seq and var gene analysis.