Elizabeth Conibear

The paper identifies two intramolecular interfaces that regulate WDR44 conformation and Rab11 binding, showing how pathogenic mutations disrupt this regulation.

This paper identifies VINE as a dual Rab regulator that activates Ypt10 and suppresses Vps21 to control late endosomal Rab signaling in yeast.

The paper identifies VINE, a VPS9-family GEF complex, as a regulator of Rab5 inactivation through phosphatase recruitment and GAP-mediated dephosphorylation.

The paper identifies septins as AP-3-associated factors in yeast, showing that Cdc11-containing septin assemblies specifically support AP-3-dependent cargo sorting to the vacuole/lysosome.

The paper identifies a conserved adapter protein and cis-acting sequences that mediate BLTP2 targeting to ER-PM contact sites in Drosophila.

This study uses molecular dynamics simulations to reveal the mechanism of lipid transport by BLTPs, showing membrane destabilization is critical for lipid desorption.

The paper shows that Vps13 binds adaptors via a shared PxP motif interface, but this interface is not required for its vacuolar protein sorting function.

The paper identifies TMEM170 family proteins as lipid scramblases that physically interact with BLTP1/Csf1, revealing a new mechanism for lipid transport between organelles.

This study identifies two regulatory elements in ABHD17 enzymes that modulate their activity through S-acylation and membrane interactions.

This study identifies Hoi1 as an adaptor that targets BLTP2-like proteins to ER-PM contact sites in yeast, regulating lipid homeostasis and showing conservation in worms and flies.

The paper identifies a disease-causing mutation in VPS13D that disrupts adaptor binding and membrane recruitment in yeast, supporting a conserved role for the VAB domain.