Author

Margaret Liu

The Ohio State UniversityORCID 0000-0002-4617-9750Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Anusua SarkariD· 2 shared Lufang ZhouiD· 2 shared Kai CheniD· 1 shared Li Zhu· 1 shared Matthew David RingeliD· 1 shared Patrick ErnstiD· 1 shared Seulhee KimiD· 1 shared Tanvi VaradkariD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

Anusua SarkarORCID

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2 papers

Recent·Most cited

Pannexin 2 restrains ER stress-induced Ca2+ dysregulation and inflammatory cardiomyocyte death

Anusua Sarkar, Li Zhu, Margaret Liu, Lufang Zhou

This study identifies Panx2 as a regulator of ER stress-induced Ca2+ dysregulation and inflammatory cardiomyocyte death, showing its role in stabilizing Ca2+ homeostasis and limiting PERK-driven signaling.

bioRxiv · Jan 28, 2026 · PreprintCell Biology

An Innovative Mitochondrial-targeted Gene Therapy for Cancer Treatment

Kai Chen, Patrick Ernst, Anusua Sarkar, Seulhee Kim, Yingnan Si, Tanvi Varadkar, Matthew David Ringel, Margaret Liu, Lufang Zhou

This paper introduces mLumiOpto, a mitochondrial-targeted gene therapy that disrupts cancer cell mitochondria using light-activated proteins, showing efficacy in reducing tumor burden in mouse models.

Cancer Research · Sep 17, 2024Peer-reviewedCancer Biology