Author

Leslie E. Silberstein

Boston Children's HospitalORCID 0000-0002-4624-0013Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Daniel Geoffrey TeneniD· 2 shared LI ChaiiD· 2 shared Nikki R. Kong· 2 shared Alicia J. Stein· 1 shared Alicia Stein· 1 shared Ashwin UnnikrishnaniD· 1 shared Chan-Shuo WuiD· 1 shared Chong Gao· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Daniel Geoffrey TenenORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJul 10, 2020

Induction of a SALL4-dependency for targeted cancer therapy

Junyu Yang, Chong Gao, Miao Liu…·LI Chai

This study shows that SALL4 can be induced in cancer cells to make them dependent on it, enabling targeted therapy with drugs like DAC and ENT.

DOI 10.1101/2020.07.10.197434

humanexperimental assay

𝕏 PostBluesky

Molecular BiologyCell ReportsPeer-reviewedJan 1, 2020

Zinc finger protein SALL4 functions through an AT-rich motif to regulate gene expression

Nikki R. Kong, Mahmoud Adel Bassal, Hong Kee Tan…·Li Chai

The paper identifies the DNA binding domain and sequence of SALL4, discovers its target genes in liver cancer cells, and reveals its mechanism of gene regulation.

56 citations

𝕏 PostBluesky