Author

Nikki R. Kong

Brigham and Women's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Daniel Geoffrey TeneniD· 2 shared Leslie E. SilbersteiniD· 2 shared LI ChaiiD· 2 shared Alicia J. Stein· 1 shared Alicia Stein· 1 shared Ashwin UnnikrishnaniD· 1 shared Chan-Shuo WuiD· 1 shared Chong Gao· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Daniel Geoffrey TenenORCID

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2 papers

Recent·Most cited

Induction of a SALL4-dependency for targeted cancer therapy

Junyu Yang, Chong Gao, Miao Liu, Zhiyuan Chen, Yao-Chung Liu, Junsu Kwon, Jun Qi, Xi Tian, Alicia Stein, Yanjing Liu, Nikki R. Kong, Yue Wu, Shenyi Yin, Jianzhong Xi, Hongbo Luo, , LI Chai

This study shows that SALL4 can be induced in cancer cells to make them dependent on it, enabling targeted therapy with drugs like DAC and ENT.

bioRxiv · Jul 10, 2020 · PreprintCancer Biology

Zinc finger protein SALL4 functions through an AT-rich motif to regulate gene expression

Nikki R. Kong, Mahmoud Adel Bassal, Hong Kee Tan, Jesse V. Kurland, Kol Jia Yong, John J. Young, Yang Yang, Fudong Li, Jonathan D. Lee, Yue Liu, Chan-Shuo Wu, Alicia J. Stein, Hongbo Robert Luo, Leslie E. Silberstein, Martha L. Bulyk, , Li Chai

The paper identifies the DNA binding domain and sequence of SALL4, discovers its target genes in liver cancer cells, and reveals its mechanism of gene regulation.

Cell Reports · Jan 1, 2020Peer-reviewedMolecular Biology