The paper tests for axon initial segment (AIS) structural plasticity in human, mouse, and rat cortical neurons across different conditions and finds no evidence of AIS length changes over short-term activity modulation.

bioRxiv · Sep 1, 2025 · PreprintNeuroscience

Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus

Mary O’Keeffe, Sam A. Booker, Darren A. Walsh, Mosi Li, Chloe Henley, Laura Simões de Oliveira, Mingshan Liu, Xingran Wang, María Banqueri, Katherine Ridley, Kosala N. Dissanayake, Cristina Martinez‐Gonzalez, Kirsty J. Craigie, Deepali Vasoya, Tom Leah, , Giles E. Hardingham

This study shows that neurodevelopmental processes in the cortex and thalamus can occur normally without microglia, using a genetically modified mouse model.

Nature Neuroscience · Jan 6, 2025Peer-reviewedNeuroscience

Enhanced hippocampal LTP but typical NMDA receptor and AMPA receptor function in a novel rat model of CDKL5 deficiency disorder

Laura Simões de Oliveira, Heather O’Leary, MS Nawaz, Rita M. Loureiro, Elizabeth C. Davenport, Paul S. Baxter, SR Ribeiro dos Louros, OR Dando, E Perkins, Emily K. Osterweil, GE Hardingham, MA Cousin, S Chattarji, SA Booker, TA Benke, , Peter C. Kind

This study investigates synaptic function in a Cdkl5 KO rat model of CDKL5 deficiency disorder, finding normal NMDA and AMPA receptor function but altered synaptic density and plasticity.

bioRxiv · Jun 29, 2022 · PreprintNeuroscience