Yuekang Zhang

CryoGO provides a method to generate high-resolution structural data of endogenous macromolecules from cells using cryo-EM, enabling detailed structural profiling with minimal sample requirements.

This study reveals how TACO1 enhances mitochondrial translation efficiency by stabilizing tRNA and promoting ribosomal translocation, with implications for bacterial orthologs.

The paper uses in situ cryo-EM to visualize human ribosome structures and functional states, revealing new protein interactions and polysome interfaces.