Samuel S. Slattery

Multiplex Gene Editing Suppresses Random Integration of Hepatitis B Virus DNA in Chronically Infected Liver

This study uses CRISPR-Cas9 to reduce HBV DNA in infected cells, showing it suppresses random integration without affecting chromosomal translocations.

PHYCUT: Scalable multiplex CRISPR/Cas9 editing forgenome engineering in the diatom Phaeodactylumtricornutum

The paper develops PHYCUT, a CRISPR/Cas9 system for multiplex genome editing in the diatom Phaeodactylum tricornutum, demonstrating its use to reduce fucosylation of secreted proteins.

Telomere-to-telomere genome assembly of Phaeodactylum tricornutum

This paper presents a telomere-to-telomere genome assembly of Phaeodactylum tricornutum using Oxford Nanopore long reads, identifying 25 nuclear chromosomes and improving genetic engineering opportunities.

Cas9-generated auxotrophs of Phaeodactylum tricornutum are characterized by small and large deletions that can be complemented by plasmid-based genes

The paper characterizes Cas9-generated auxotrophs in Phaeodactylum tricornutum, showing they can be complemented by plasmid-based genes and exhibit metabolic changes.