Modulation of SARS-CoV-2 spike binding to ACE2 throughconformational selection
Prithwidip Saha, Ignacio Fernandez, Fidan Sumbul, Claire Valotteau, Dorota N. Kostrz, Annalisa Meola, Eduard Baquero, Arvind Sharma, James R. Portman, François Stransky, Thomas Boudier, Pablo Guardado‐Calvo, Charlie Gosse, Terence R. Strick, Felix Augusto Rey, Félix Rico
This study uses single-molecule techniques to show that SARS-CoV-2 spike protein RBD dynamics modulate ACE2 binding through conformational selection without affecting unbinding.
Nature Nanotechnology · Jun 10, 2025Peer-reviewedBiophysics