Félix Rico

A non-invasive approach to study localized forced in 3D epithelia

This paper introduces a non-invasive method to study localized mechanical forces in 3D epithelial tissues using elastic microbeads and shows how cytoskeletal remodeling and adhesion organization respond to mechanical perturbations.

Scaling the Dynamics of Coiled Coils

This study uses HS-AFM to visualize coiled coil dynamics in MR complexes, revealing power-law scaling and long relaxation times due to internal friction.

EpCAM sustains crypt mechanics and prevents aberrant remodeling

This study identifies EpCAM as a key regulator of epithelial contractility and crypt morphogenesis, showing its role in maintaining crypt structure and preventing aberrant remodeling.

PySteMoDA: An Open Source Python Package for the Analysis of Steered Molecular Dynamics Simulations Data

PySteMoDA provides an automated tool for analyzing steered molecular dynamics simulations, improving accuracy and accessibility in computational biochemistry and biophysics.

Near equilibrium unbinding of streptavidin/biotin using single molecule acoustic force spectroscopy.

This study uses acoustic force spectroscopy to measure streptavidin-biotin bond dissociation rates near equilibrium, aligning with bulk measurements and expanding the dynamic range of single molecule force spectroscopy.

Modulation of SARS-CoV-2 spike binding to ACE2 throughconformational selection

This study uses single-molecule techniques to show that SARS-CoV-2 spike protein RBD dynamics modulate ACE2 binding through conformational selection without affecting unbinding.

Real-time Visualization of Trigger Factor on Translating Ribosomes

This study visualizes Trigger Factor dynamics on translating ribosomes using high-speed atomic force microscopy and molecular dynamics simulations, revealing its structural flexibility and selective association with active ribosomes.