Author

James R. Portman

Centre National de la Recherche ScientifiqueORCID 0000-0002-0913-262XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Organism:yeast· 1

Frequent Co-Authors

Annalisa MeolaiD· 1 shared Arvind SharmaiD· 1 shared Charlie GosseiD· 1 shared Claire ValotteauiD· 1 shared Dorota N. KostrziD· 1 shared Eduard BaqueroiD· 1 shared Felix Augusto ReyiD· 1 shared Félix RicoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

Annalisa MeolaORCID

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2 papers

Recent·Most cited

Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewedOct 28, 2026

Dynamics of TFIIH and Spt4/5 during the transition from transcription initiation to elongation

James R. Portman, Kai Torrens, Gabriela G. Giordano…·Stephen Buratowski

The paper uses single-molecule fluorescence microscopy to show that TFIIH dissociates from RNA polymerase II before Spt4/5 binds, indicating Spt4/5 does not actively displace TFIIH.

DOI 10.1073/pnas.2614650123

yeastexperimental assay

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BiophysicsNature NanotechnologyPeer-reviewedJun 10, 2025

Modulation of SARS-CoV-2 spike binding to ACE2 throughconformational selection

Prithwidip Saha, Ignacio Fernandez, Fidan Sumbul…·Félix Rico

This study uses single-molecule techniques to show that SARS-CoV-2 spike protein RBD dynamics modulate ACE2 binding through conformational selection without affecting unbinding.

18 citationstop 1%

experimental assayhost-pathogen & immune response

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