Author

Michael H. Bott

Forschungszentrum JülichORCID 0000-0002-4701-8254Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:C. elegans· 4 Approach:experimental assay· 4 Organism:E. coli· 2 Assay:metagenomics· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. KrügeriD· 2 shared Alexander LehnertiD· 2 shared Astrid WirtziD· 2 shared Athanasios PapadopoulosiD· 2 shared Benita LückeliD· 2 shared Holger GohlkeiD· 2 shared Julia FrunzkeiD· 2 shared Meike BaumgartiD· 2 shared

Activity by Year

2026-2026 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBioengineering

A. KrügerORCID

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Author profile →

5 papers

Recent·Most cited

Microbial production of the low-caloric sweetener D-allulose from D-glucose by evolutionary engineering

Alexander Lehnert, Rocco Gentile, Claudia Tahiraj, Astrid Wirtz, Meike Baumgart, Tino Polen, Holger Gohlke, Michael H. Bott

This paper evolves microbial strains to efficiently produce D-allulose from D-glucose, achieving a 15% yield at 30°C using engineered enzymes and a chassis strain.

Trends in biotechnology · Oct 1, 2026Peer-reviewedBioengineering

Growth of Corynebacterium glutamicum on 5-oxo-L-proline (pyroglutamate) as carbon and nitrogen source requires the PxpR-controlled pxpTABC genes

Lea Sundermeyer, Christina Mack, Susana Matamouros, Michael H. Bott

This paper shows that Corynebacterium glutamicum can grow on 5-oxo-L-proline as carbon and nitrogen source, requiring the PxpR-controlled pxpTABC genes for uptake and metabolism.

Applied and Environmental Microbiology · May 29, 2026Peer-reviewedMicrobiology

Metabolic engineering of Corynebacterium glutamicum for production of the low-caloric natural sweetener D-allulose via phosphorylated intermediates

Alexander Lehnert, Maja Deditius, Astrid Wirtz, Meike Baumgart, Michael H. Bott

This paper engineers Corynebacterium glutamicum to produce D-allulose via a phosphorylation-dephosphorylation pathway, achieving a 2.3-fold increase in production in minimal medium.

Metabolic Engineering · Apr 3, 2026Peer-reviewedBioengineering

A novel biosensor for ferrous iron developed via CoBiSe:A computational method for rapid biosensor design

Athanasios Papadopoulos, Manuel T. Anlauf, Jens Reiners, S G Paik, A. Krüger, Benita Lückel, Michael H. Bott, Thomas Drepper, Julia Frunzke, Holger Gohlke, Stefanie Weidtkamp‐Peters, Sander H. J. Smits, Christoph G. W. Gertzen

The paper introduces CoBiSe, a computational method for biosensor design, and demonstrates its application in creating IronSenseR, a biosensor for ferrous iron with high specificity and sensitivity.

ACS Sensors · Jan 11, 2026Peer-reviewedBioengineering

Context-dependent siderophore exploitability shapes microbial community structure

A. Krüger, Sanga Paik, Michelle Bund, Matthias Pesch, Stephan Krueger, Benita Lückel, Athanasios Papadopoulos, Johanna Wiechert, Tanvir Hassan, Ulrike Weber, Romain Avellan, Sander H. J. Smits, Michael H. Bott, Ákos T. Kovács, Philipp Westhoff, , Julia Frunzke

The paper investigates how siderophore exploitation and spatial structure influence microbial community dynamics in iron competition.

The ISME Journal · Jan 1, 2026Peer-reviewedMicrobiology