Jennifer E. Phillips‐Cremins

This study evaluates statistical methods for identifying chromatin looping interactions in 5C data, comparing their performance across analysis steps and providing a software tool for testing these methods.

The paper introduces 5C-ID, a method that improves resolution and reduces noise in chromatin loop detection compared to standard 5C, enabling high-resolution 3D genome maps at lower cost than Hi-C.

The paper introduces a method to detect hierarchical 3D genome domain reconfiguration using network modularity analysis across cellular states.

The paper identifies that STRs causing repeat expansion disorders are located at 3-D chromatin domain boundaries, which are enriched in CpG islands and may contribute to epigenetic instability.