Niels Schneberger

The paper shows NLRP3 activators disrupt the AP2 complex and impair plasma membrane signaling, leading to inflammation and cell death.

This study identifies the SAVED domain of CalpL as a ring nuclease that cleaves cA4, revealing its role in regulating the CRISPR defense system.

This paper introduces CRISPR-READ, a live cell RNA sensor that detects endogenous transcripts and identifies Type-I interferon signaling through RNA-seq of sorted cells.