Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins
Bianca Broske, Sophie C. Binder, Benjamin A. McEnroe, Tim Noah Kempchen, Caroline I. Fandrey, Julia M. Messmer, Elisabeth Tan, Peter Konopka, Dominic Ferber, Michelle C.R. Yong, Marie Kleinert, Alexander Hoch, Katja Blumenstock, Jan M. P. Tödtmann, Johannes Oldenburg, , Michael Hölzel
This paper develops AI-designed protein binders for cancer cell surface proteins, showing their effectiveness in detection and targeting through experimental validation and benchmarking of structure prediction models.
bioRxiv · May 11, 2025 · PreprintBioengineering