Author

Kshiti Meera Phulphagar

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1

Frequent Co-Authors

Felix MeissneriD· 3 shared Annika Frauenstein· 2 shared Eicke LatziD· 2 shared Fraser Duthie· 2 shared M. S. J. ManganiD· 2 shared Matthias ManniD· 2 shared Rainer StahliD· 2 shared Stefan EbneriD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersCell Biology

Felix MeissnerORCID

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Author profile →

3 papers

Recent·Most cited

NLRP3 activators disrupt the endocytic AP2 complex and plasma membrane signaling

Stefan Ebner, Kshiti Meera Phulphagar, Yubell Alvarez, Lars Jürgenliemke, Fabian Frechen, Isabel Stötzel, Marta Lovotti, Matthew Mangan, Anil Akbal, Niels Schneberger, Annika Frauenstein, Tabea Klein, Jonathan J. Swietlik, Benedikt O. Gansen, Diana Fink, , Felix Meissner

The paper shows NLRP3 activators disrupt the AP2 complex and impair plasma membrane signaling, leading to inflammation and cell death.

bioRxiv · Feb 25, 2026 · PreprintCell Biology

Butyrate and propionate are microbial danger signals that activate the NLRP3-inflammasome in human macrophages in the presence of TLR stimulation

Wei Wang, Alesja Dernst, Bianca Martin, Lucía Lorenzi, Maria Cadefau-Fabregat, Kshiti Meera Phulphagar, Antonia Wagener, Christina F. Budden, Neil Stair, Theresa Maria Wagner, Harald Andreas Färber, Andreas Jaensch, Rainer Stahl, Fraser Duthie, Susanne V. Schmidt, , M. S. J. Mangan

The paper shows that butyrate and propionate activate the NLRP3 inflammasome in human macrophages when combined with TLR agonists, through HDAC inhibition and epigenetic changes.

Cell Reports · Sep 1, 2024Peer-reviewedImmunology

Identification of Covalent Modifications Regulating Immune Signaling Complex Composition and Phenotype

Annika Frauenstein, Stefan Ebner, Fynn M. Hansen, Ankit Sinha, Kshiti Meera Phulphagar, Kirby N. Swatek, Daniel Hornburg, Matthias Mann, Felix Meissner

The paper introduces a method to identify covalent modifications and protein interactions regulating immune signaling complex composition and function in monocytes.

Molecular Systems Biology · Jul 1, 2021Peer-reviewedSystems Biology