Author

Gabriele Jessica Kembuan

Massachusetts General HospitalORCID 0000-0002-4706-3573Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Adam David DurbiniD· 1 shared Adam Samuel SperlingiD· 1 shared Alfonso Lavado· 1 shared Alisha KardianiD· 1 shared Amanda BlandiD· 1 shared Amelia Hancock· 1 shared Amir ArabzadeiD· 1 shared Andi Cheng· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Adam David DurbinORCID

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2 papers

Recent·Most cited

A Lenalidomide-Inducible Suicide Switch for Gene- and Cell-Based Therapy

Ditsa Sarkar, William Lin, Nelson H. Knudsen, Jalen Evans, Joanna Kim, Stephen M. Coscia, Isabel C. Lane, Andi Cheng, Noor Radde, Manuella Talla Takoukam, Angelique Pham, Tamina Kienka, Emily Schneider, Gabriele Jessica Kembuan, Mikolaj Michal Slabicki, , Max Jan

This paper introduces a lenalidomide-inducible suicide switch for gene- and cell-based therapies that enables safe and effective cell depletion without detectable leakiness.

bioRxiv · Oct 1, 2026 · PreprintSynthetic Biology

Dominant Malignant Clones Leverage Lineage Restricted Epigenomic Programs to Drive Ependymoma Development

Alisha Kardian, Hua Sun, Siri Manasa Ippagunta, Nic Laboe, Srinidhi Varadharajan, Kwanha Yu, Hsiao‐Chi Chen, Erik Emanus, Tuyu Zheng, Riley M. Deneen, Jon P. Connelly, Yong-Dong Wang, Jiangshan Zhan, Hengxi Liu, Kimberley Lowe, , Stephen C. Mack

This study identifies specific developmental epigenomic states that enable ZFTA-RELA-driven ependymoma formation and reveals how these states shape tumor progression.

Nature · Mar 25, 2026Peer-reviewedCancer Biology