Xiaoyan Wei

Integrative enhancer discovery identifies functional enhancer dependencies in pediatric acute myeloid leukemia

This study identifies functional enhancer dependencies in pediatric AML using an integrative approach, revealing H-ME as an RNA-independent regulator of MYB.

A platform of robust patient-derived leukemia models covering subgroups for which no cell lines exist

The paper develops patient-derived AML PDX models that replicate primary AML biology and include subgroups lacking existing models, showing reduced leukemia growth after long-term chemotherapy.

Cell autonomous requirement of Neurofibromin (Nf1) for postnatal muscle hypertrophic growth and metabolic homeostasis

This study shows that Nf1 is required for postnatal muscle growth and metabolic homeostasis, with loss of Nf1 causing muscle atrophy and metabolic changes.