Angela M. Hancock

Dissecting the genetic basis of drought escape across multiple traits in colonizing Arabidopsis thaliana lineages

This study identifies genetic factors underlying drought escape adaptation in Arabidopsis thaliana by analyzing multiple traits and genome-wide associations.

Natural variation in an NLR pair confers thermostable resistance to a devastating bacterial pathogen

The paper identifies a natural genetic variant in the RPS4/RRS1 NLR pair that confers thermostable resistance to Ralstonia pseudosolanacearum in Arabidopsis thaliana.

Major effect mutations drive DNA methylation variation after colonization of a novel habitat

The paper identifies three high-impact mutations in Arabidopsis thaliana that drive DNA methylation variation during colonization of the Cape Verde Islands.

Mapping genetic modifiers of epimutation rates reveals a punctuated-equilibrium model of CG methylome evolution

The paper tracks DNA methylation across generations in Arabidopsis lineages to identify a genetic modifier that increases epimutation rates and supports a punctuated-equilibrium model of methylation evolution.

Towards an unbiased characterization of genetic polymorphism

The paper analyzes whole-genome polymorphism data from 27 Arabidopsis thaliana genomes to highlight challenges and insights in unbiased genetic variation characterization.

Linked-read sequencing of gametes allows efficient genome-wide analysis of meiotic recombination

The paper develops a linked-read sequencing method to efficiently identify meiotic crossovers at kilobase resolution in pooled recombinants, validated in Arabidopsis.

Gene expression drives the evolution of dominance

The paper uses population genomic data to characterize the degree of dominance for new mutations and develops a new theory for its evolution.