Ian Cossentino

Cell signaling pathways discovery from multi-modal data

The paper introduces Incytr, a method for discovering cell signaling pathways from multi-omics data, demonstrating its application in disease contexts and showing its utility for drug discovery and understanding cell communication.

A heteromeric nicotinic acetylcholine receptor promotes sleep by relaying GABAergic signals within a locus of motor and sensory integration

This study identifies a heteromeric nicotinic acetylcholine receptor in Drosophila that promotes sleep by relaying GABAergic signals in the ventral nerve cord.

A global atlas of substrate specificities for the human serine/threonine kinome

Positional scanning peptide arrays profile substrate sequence specificities across 303 human serine/threonine kinases, enabling computational kinase-substrate annotation and signaling pathway inference across the human phosphoproteome.