Denis Dupuy

The paper develops a method to analyze high-coverage single-cell RNA-seq data to identify gene expression patterns in C. elegans cells without dimensional reduction.

This study uses a C. elegans model to show that SMN-1 deficiency causes developmental and degenerative defects in motor and touch receptor neurons, suggesting conserved SMA pathology.

This study identifies RET-1d as an ER-phagy receptor mediating heat stress adaptation in C. elegans by promoting autophagosome biogenesis in neurons and epidermis.

The paper quantifies trans-splicing in C. elegans mRNAs using Nanopore sequencing, revealing terminal hairpins in non-trans-spliced mRNAs.

This study introduces inverse toeprinting to map ribosome arrest sites on mRNA and identifies sequence-specific arrest motifs for ribosome-targeting antibiotics.

The paper analyzes RNA-seq data from C. elegans to quantify alternative exon usage and identifies robust splicing events, revealing patterns of splicing conservation and trans-splicing prevalence.