Mitochondrial Integrated Stress Response Activation Creates a Therapeutic Vulnerability to MCL-1 Inhibition in Acute Myeloid Leukemia
Lauren Brakefield, Amit Budhraja, Peter A. Hall, Dixie Brewington, Jamila Moore, Josi Lott, Yonghui Ni, Dennis Voronin, Oliver Grant-Chapman, Tresor O Mukiza, Tristen Wright, Yong‐Dong Wang, Sandi Radko-Juettner, Shondra M. Pruett‐Miller, Stanley B Pounds, , Joseph T. Opferman
This study identifies co-targeting of MCL-1 and ETC complex I as a synergistic therapy for high-risk AML, showing improved viability reduction and survival in preclinical models.
Cell Death and Disease · Jun 25, 2026Peer-reviewedCancer Biology