Author

Sandi Radko-Juettner

St. Jude Children's Research HospitalORCID 0000-0002-6969-5184Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Josi LottiD· 2 shared Stanley B PoundsiD· 2 shared Alex KentsisiD· 1 shared Ali KhalighifariD· 1 shared Amit BudhrajaiD· 1 shared Aurelie ClaquiniD· 1 shared Bappaditya ChandraiD· 1 shared Benjamin A. GarciaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCancer Biology

Josi LottORCID

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Author profile →

2 papers

Recent·Most cited

Mitochondrial Integrated Stress Response Activation Creates a Therapeutic Vulnerability to MCL-1 Inhibition in Acute Myeloid Leukemia

Lauren Brakefield, Amit Budhraja, Peter A. Hall, Dixie Brewington, Jamila Moore, Josi Lott, Yonghui Ni, Dennis Voronin, Oliver Grant-Chapman, Tresor O Mukiza, Tristen Wright, Yong‐Dong Wang, Sandi Radko-Juettner, Shondra M. Pruett‐Miller, Stanley B Pounds, , Joseph T. Opferman

This study identifies co-targeting of MCL-1 and ETC complex I as a synergistic therapy for high-risk AML, showing improved viability reduction and survival in preclinical models.

Cell Death and Disease · Jun 25, 2026Peer-reviewedCancer Biology

MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia

Nicole Lynn Michmerhuizen, Emily Heikamp, Ilaria Iacobucci, Masayuki Umeda, Bright Arthur, Vibhor Mishra, Chun Shik Park, Danika Di Giacomo, Ryan Hiltenbrand, Qingsong Gao, Sandi Radko-Juettner, Josi Lott, Cynthia Martucci, Varsha Subramanyam, Charlie Hatton, , Charles Grenfell Mullighan

This study identifies MOZ and HBO1 as molecular dependencies in NUP98-rearranged AML, showing their inhibition reduces leukemic burden and synergizes with Menin inhibitors.

Cancer Discovery · Jun 19, 2025Peer-reviewedCancer Biology